FASCINATION ABOUT 6''-O-ACETYLSAIKOSAPONIN A

S1P could be dephosphorylated to sphingosine by sphingosine phosphatases and will be irreversibly degraded by an enzyme, sphingosine phosphate lyase.S1P/S1PR axes also are important in controlling vascular tone and permeability. S1P while in the circulation regulates basal and inflammation-induced vascular leak by means of S1PR1 21. TNF-α induces